Today, marketing knowledge-based companies in the field of medical technology plays a vital role in commercializing scientific innovations and improving the health of society. These companies, using specialized knowledge and advanced technologies, seek to develop products that respond to medical needs in an accurate and innovative manner. The present study on designing marketing knowledge-based companies in medical technology is based on interpretive structural modeling. This research is exploratory in terms of purpose and qualitative in terms of approach. In this study, 17 experts were interviewed. The snowball method was used to collect information, and then the information extracted from the texts and interviews was categorized and analyzed using the content analysis method. Considering the intended goals, semi-structured interviews and text review based on the content analysis strategy were used to collect data. Finally, 70 primary themes, 13 basic themes, 6 organizing themes, and 1 overarching theme were classified. The findings show that market analysis and challenges and opportunities play a role as underlying factors at the lowest level. These factors provide the basis for the emergence of market strategy, product development, advertising, and customer orientation, which are at the middle level of the model. This category directly affects the distribution and sales of medical products. The research findings can help managers of these companies to gain competitive advantage and increase their share in domestic and international markets by adopting appropriate marketing strategies.